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Cytosolic malic enzyme normally only operates toward decarboxylation

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Although, molecular glue approaches have not yet been broadly applied to KRAS-targeted therapy, their success in modulating previously challenging targets highlights he growing potential of target protein degradation as a therapeutic strategy

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It is secreted from the ciliary epithelium

Moreover, ILDR enhances the efficacy of ICI through microbiota- and BA-mediated mechanisms, including increased DC activation and CD8+ T cell recruitment, potentially driven by DCA enrichment ( Together, these findings suggest that targeting the microbiotaBA axis may improve the efficacy and tolerability of chemoradiotherapy