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The proposed mechanism involves green tea acting as an antioxidant, scavenging reactive oxygen species and thereby reducing nuclear factor-B activity, a key regulator of inflammation

TABLE 2 Log-fold change of ferroptosis-related DEGs in glia cells in AD

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The SSc-ILD is most likely to progress during the first 4 years of systemic disease and especially in the first 2 years and in a small subset of patients, in whom lung disease precedes the cutaneous manifestations of SSc 3

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As a result, SAM is converted subsequently to S-adenosylhomocysteine and homocysteine which in turn, can be remethylated back to methionine or can be further metabolised in the transsulfuration pathway to form cysteine, in a B 6 -dependent process (Reference Bottiglieri11)