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The authors would like to thank the clinicians and researchers whose work provided the foundational insights for this review

For example, metformin-loaded nanoparticles attenuate hyperglycemia-associated oxidative stress and promote eNOS phosphorylation in vascular endothelial cells (Mohamed et al., 2024), supporting the feasibility of nanoparticle-based drug delivery strategies

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Methods Thirty-six adult male Wister albino rats were subgrouped into six groups