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The irony, as you point out, is that this same rigidness does not apply to other medications that can be prescribed in a more flexible manner

The original paper described the block utilizing landmark techniques and tactile feel during block performance, though the associated risk of pneumothorax was likely responsible for the technique falling out of favor

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Here we report that these two oncogenic pathways may not act in concert, but act apparently partially antagonistic at least in human GIC models, potentially accounting for disappointing results with inhibition of either pathway in the clinic 29,30,31 , but also providing new concepts on how to modulate these pathways more efficiently to improve the outcome of glioblastoma

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10.1016/j.neuint.2012.10.001 Neurochem