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Furthermore, the relative abundance of Akkermansia , a genus positively associated with improvements in obesity-related metabolic issues 60 , was increased in the vehicle-treated group that underwent diet switch relative to the WD control group, suggesting a potential for distinct microbiome-mediated mechanisms of weight loss subsequent to diet switch from those of diet switch in combination with 5A-1MQ treatment

The Journal of nutrition , 136 (6), 1731S1740S

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Patients on lipotropic protocols are simultaneously dieting, exercising, and being weighed by a clinician every few weeks