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doi: 10.1111/bcp.16233 DATA AVAILABILITY STATEMENT Data sharing is not applicable to this article as no new data were created or analyzed in this study

Histidine tags have strong affinity for metal ions

Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression