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doi: 10.1093/cvr/cvn098

Extracellular signal-regulated kinase (ERK)-mediated phosphorylation of MFN1 (HR1 domain) suppresses fusion and promotes apoptosis, whereas JNK phosphorylation of MFN2 targets it for ubiquitination by E3 ligases and proteasomal degradation, resulting in mitochondrial fragmentation and increased apoptosis

Data analysis after study completion showed a trend, and it is displayed in Fig

[] Although both proteins reside on the OMM, MFN2 additionally localizes to the ER, facilitating ERmitochondria tethering, which is essential for inter-organelle calcium transfer

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However, like many people have commented, 9 days later I got a baseball size red rash around the injection site that was hard to the touch