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The citric acid cycle involves three NAD+-dependent dehydrogenase reactions: isocitrate dehydrogenase, -ketoglutarate dehydrogenase, and malate dehydrogenase, each generating NADH while releasing carbon dioxide and regenerating oxaloacetate for continued cycle operation

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In UC, the inflammation is restricted to the rectum and the colon and never affects the small intestine

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Kristiansen M., Kozyraki R., Jacobsen C., Nexo E., Verroust P.J., Moestrup S.K