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chalepensis caused no significant acute or chronic mortality in mice at 3,000 mg/kg

Conversely, a diet rich in natural antioxidantsespecially from fruits, vegetables, nuts, and polyphenol-rich oilshelps neutralize free radicals and limit glycation

This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier

Inhibition of the COX2-PGE2 axis increases immune cell infiltration within the TME and rescues cytotoxic CD8 + T-cell activity, thus suppressing tumors by resensitizing pembrolizumab-resistant tumors [183]

Hormones, peptides, complex amino acid chains, play an important role in the signaling networks that guide our bodies