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Most of the cancers required higher doses of methotrexate which may induce the renal dysfunction and subsequently decreases its renal clearance

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Although not much is known about these enzymes in cancer, the CHAC2 isoform has already been classified as a tumour suppressor gene in gastric and colorectal cancer, on the basis of its downregulation being associated with more aggressive cancer variants and its activation-inducing apoptosis in cancer cells