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Long-acting muscarinic antagonists (LAMAs), such as tiotropium and aclidinium, reduce acetylcholine-mediated bronchoconstriction and suppress mucus hypersecretion by inhibiting goblet cell and submucosal gland activity [78, 79]

In preclinical cancer models, COX-2 inhibition reduces tumor growth in COX-2-expressing tumors, and the pharmacodynamic readout is the reduction in tumor PGE2 concentration

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