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doi: 10.1172/jci.insight.123672 61 MacdonaldKGHoeppliREHuangQGilliesJLucianiDSOrbanPCet al

In conclusion, the regulatory hurdles, toxicity, and long-term stability of retinal nanomedicines pose major challenges in clinical practice

Strains deleted for both genes are viable, but lack heatstable oxidoreductase activity with hydroxyethylene disulphide as a model disulphide substrate

The only notable exception is DHARs, for which DHA reduction is truly relevant

In our preparations, densely packed 2(CENP-A/H4) 2 octasomes also form looser, flexible fibers reminiscent of archaeal-like histone polymers (31, 32, 38), suggesting a packing mode that could contribute to centromere-specific chromatin features