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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

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Nuclear miRNAs have diverse functions, including direct modulation of cis-regulatory elements such as promoters and enhancers [36,37,38], regulation of the transcription factor activities [39, 40], interaction with chromatin modifiers like EZH2 [41], regulation of microprocessing machinery [42, 43], and remodeling of the chromatin architecture [44]

Efficacy and safety of nivolumab plus ipilimumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib: the CheckMate 040 randomized clinical trial