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6A), whereas the PPIs of the Uni-SP-ROT group were enriched in mitochondrial electron transport and mitochondrial respiratory chain complex I assembly functions (Supplementary Fig

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The expression of PGC1 and OXPHOS activities are increased in the long-living Ames dwarf mice (lack of GH, prolactin, and thyroid-stimulating hormone), demonstrating a negative effect of GH on mitochondrial biogenesis (Westbrook et al., 2009