No major safety signals were identified, and heterogeneity across outcomes was low to moderate
Abbreviations DM: Diabetes Mellitus IDF: International Diabetes Federation CVD: Cardiovascular diseases T1DM: Type 1 Diabetes Mellitus T2DM: Type 2 Diabetes Mellitus GBD: Global Burden of Disease ASCVD: Atherosclerotic Cardiovascular Disease HFPG: High Fasting Plasma Glucose LDL: Low-Density Lipoprotein HbA1c: Glycated Hemoglobin FPG: Fasting Plasma Glucose EASD: European Association for the Study of Diabetes ADA: American Diabetes Association AACE: American Association of Clinical Endocrinologists CHD: Coronary Heart Disease PPG: Postprandial Plasma Glucose NIDDM: Non-Insulin-Dependent Diabetes Mellitus MI: Myocardial Infarction OGTT: Oral Glucose Tolerance Test PKC: Protein Kinase C HBP: Hexosamine Biosynthetic Pathway AR: Aldose Reductase SDH: Sorbitol Dehydrogenase NADPH: Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form) GSH: Glutathione ROS: Reactive Oxygen Species NO: Nitric Oxide NAD + : Nicotinamide Adenine Dinucleotide NADH: Nicotinamide Adenine Dinucleotide (Reduced form) AGEs: Advanced Glycation End-products CVS: Cardiovascular System ECs: Endothelial Cells AF: Atrial Fibrillation CHF: Congestive Heart Failure CAD: Coronary Artery Disease sRAGE: Soluble Receptors for AGEs esRAGE: Endogenous Secretory RAGE hsCRP: High-Sensitivity C-Reactive Protein TNF: Tumor Necrosis Factor IL-6: Interleukin-6 CML: N-(Carboxymethyl)lysine DAG: Diacylglycerol PKC: Protein Kinase C DHAP: Dihydroxyacetone Phosphate G3P: Glycerol-3-Phosphate GAPDH: Glyceraldehyde-3-Phosphate Dehydrogenase GAP: Glyceraldehyde-3-Phosphate VSMC: Vascular Smooth Muscle Cells RBX: Ruboxistaurin ETC: Electron Transport Chain FADH 2 : Flavin Adenine Dinucleotide (Reduced Form) ATP: Adenosine Triphosphate ADP: Adenosine Diphosphate TGF-1: Transforming Growth Factor Beta 1 PAI-1: Plasminogen Activator Inhibitor-1 G6PD: Glucose-6-Phosphate Dehydrogenase PPP: Pentose Phosphate Pathway NOX: NADPH Oxidase XO: Xanthine Oxidase Ang II: Angiotensin II K ATP : ATP-Sensitive Potassium Channel ONOO : Peroxynitrite O : Superoxide Radicals eNOS: Endothelial Nitric Oxide Synthase BH 4 : Tetrahydrobiopterin NAC: N-acetyl-L-cysteine CoQ10: Coenzyme Q10 Mito Q: Mitoquinone Mesylate ALA: Alpha-Lipoic Acid HBP: Hexosamine Biosynthetic Pathway GFPT: Glutamine-Fructose-6-Phosphate Transaminase UDP-GlcNAc: Uridine Diphosphate N-Acetylglucosamine O-GlcNAc: O-Linked N-Acetylglucosamine OGT: O-GlcNAc Transferase OGA: O-GlcNAcase ER: Endoplasmic Reticulum SERCA: Sarco/Endoplasmic Reticulum Ca 2 + -ATPase BAD: BCl - 2-Associated Death Promoter AMPK: Adenosine Monophosphate-Activated Protein Kinase mTOR: Mechanistic Target Of Rapamycin VCAM-1: Vascular Cell Adhesion Molecule-1 ICAM-1: Intercellular Adhesion Molecule-1 References Yameny AA
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Pharmacological mechanism of shaoyao gancao decoction in the treatment of depression based on bioinformatics and animal experiment
The six-fold decline between 1962 and 1987 in annual hospital admissions with the disease in Kerala province, south India, coincides with the introduction of electricity, which removed the dependence on traditional lighting (34)
While different studies have shown the inverse association between IL-6, TNF-, CRP, and serum zinc levels in adults aged 40 [36]
