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Abstract Nitric oxide (NO) plays a prominent physiological role as a low-molecular-mass signal molecule involved in diverse biological functions

However, in the intervention process of ferroptosis, it was found that the application of GPX4 inhibitors could not completely block the occurrence of ferroptosis [18, 19], and some ferroptosis was also found in the process of tumour intervention

doi: 10.1073/pnas.2101718118 43 CircuM

Therefore, NO can mediate ROS-induced lipid peroxidation (LPO)

The stained cells were incubated at 37 C for 30 min and observed with a CLSM