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These are the two diseases where more than three-quarters of the deaths from these causes are attributable to smoking, although similar conditions such as cancer of the larynx (79% for men and 71% for women) and chronic airway obstruction (77% for men and 74% for women) also have high rates of mortality linked to smoking

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Caffeine and nicotine have specific pharmacological interactions that make their combined use neurologically more rewarding than either substance alone and that create specific challenges for smokers trying to quit

doi:10.3322/canjclin.30.5.295

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