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Commonly Reported Side Effects Most of the side effects described online are mild and include: Injection-site redness or irritation Bruising Headache Nausea Temporary fatigue These reports are largely anecdotal and should not be treated as definitive safety data

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Two studies involved intravenous injection, and four studies involved an oral tablet

Fanelli S, Francioso A, Cavallaro R, et al

Methods The keywords meniscal tear, 'meniscal repair, degenerative tea, ramp lesion, combined with AND for Platelet-rich plasma (PRP) therapy OR PRP treatment OR PRP injections, were searched in the database PubMed, Medline, and EMBASE

This makes targeting the Nrf2GPX4 pathway a highly promising and important direction for developing OA disease-modifying therapies (Figure 1)