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Description

When your levels drop, everything slows down

Phase 1 study of CB-839, a first-in-class, orally administered small molecule inhibitor of glutaminase in patients with relapsed/refractory leukemia

Front Pharmacol 3:141

Nanoscale 10 , 41794188 (2018)

Plos One 18 (11), e0294280

In LSS, the expression of the E3 ubiquitin ligase Smurf1 is markedly elevated, which promotes fibrosis and oxidative stress in LF cells, contributing to the progression of LSS by facilitating the ubiquitination and degradation of NRF2 [112]