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Romani A et al (2020) Arylesterase activity of paraoxonase-1 in serum and cerebrospinal fluid of patients with Alzheimers disease and vascular dementia

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What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug