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Future efforts should focus on overcoming delivery challenges using nanoparticle-based carriers, improving mitochondrial engraftment via mitochondrial fitness enhancement, and tailoring interventions using patient-derived cells or organoids

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Iron deficiency per se and iron deficiency-induced hypoxia can trigger the activation of HIFs, which are known to mediate cancer progression by upregulating target genes associated with angiogenesis and the metabolic reprogramming of tumor cells (106, 107), thus causing resistance to chemo- and radiotherapies (108, 109)