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Sochman, J., N-Acetylcysteine Somewhere Between Scylla and Charybdis

for example, it protects membranes by maintaining the reduced state of both -tocopherol and zeaxanthin, it prevents the oxidative denaturation of proteins under stress conditions by protecting their thiol groups, and it serves as a substrate for both glutathione peroxidase and glutathione S -transferase

The authors concluded that "those with ASDs are affected by an imbalance between their anti-oxidative and oxidative stress systems, a condition which could be treated with glutathione supplementation"

Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

doi:10.1161/circgenetics.113.000208

Molecular characterization, regulation, heterologous expression, and enzyme properties