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Moreover, the HIV infection also causes mild neurocognitive disorder and demyelinating neuropathy with motor and sensory impairments

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Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase

Once it enters the cytoplasm, a part of Cu + binds to glutathione (GSH) and is delivered to metallothionein 1/2 (MT1/2) to be restored, and other parts of Cu + are either transferred to the nucleus or ATP7A/7B located in the trans-Golgi network (TGN) by the chaperone antioxidant-1(ATOX1) to facilitate the synthesis of cuproenzymes (Lutsenko et al., 2007) or delivered to superoxide dismutase 1 (SOD1) in the cytoplasm and mitochondrial intermembrane space by a copper chaperone for superoxide dismutase (CCS) to detoxify reactive oxygen species (ROS)

4.2.2 Interruption of lipid peroxidation inhibits ferroptosis Lip-1 plays a pivotal role in modulating ferroptotic processes by effectively neutralizing lipid peroxides and free radicals (Sheng et al., 2017)

This finding supports the notion that nanoparticles can alter the physicochemical properties of hydrophobic compounds (FIN and CUR), thereby expanding their therapeutic potential