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Daiger SP, Sullivan LS, Bowne SJ

& Wirrell, E

This paper categorizes ALI into various types, including those caused by pneumonia, trauma, inhalation, mechanical ventilation, sepsis, pulmonary ischemia/reperfusion injury, hypoxia, pharmacological agents, blood transfusions, severe acute pancreatitis, toxins, radiological treatments, and fever (Figure 1)

The copper ion is bound to either three or four histidine side chains, and may also be bound to either water or superoxide, depending on the copper oxidation state and the step in the catalytic cycle (see Figure below)

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