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Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination

56 In clinical studies, purple grape juice lowered platelet reactivity in healthy subjects

This further causes oxidative stress and inflammation in animal lungs, which is evidence of tissue damage

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Thus, by lacking SIRT1 activity, ageing results in a scenario where AMPK is activated due to energy-scarce conditions, but this results in mitotic arrest through phosphorylation of p53 and increasing p16 expression (Wiley et al, 2016)