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Interestingly ATM deficient patients can sometimes present with early aging phenotypes including canities or with the pigment disorder vitiligo 56 and mice lacking ATM can also display coat and tail pigmentation abnormalities particularly after genotoxic insult 59

P., Atwood C

1 was discontinued due to elevated liver enzymes due to their psychiatric medication

Dalle-Donne, I., Rossi, R., Giustarini, D., Colombo, R

Treatment strategies can be categorized based on their targets, including the disruption of excitotoxicity, management of oxidative stress and mitochondrial dysfunction, treatment of inflammation and abnormal immune responses, modulation of glial cells, and the use of gene and stem cell therapies

c-type (common or chicken), g-type (goose), and i-type (invertebrate), with principal differences in biochemical/enzymatic properties and amino acid sequence [8]