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Studies have highlighted the increasing importance of MetS, which is characterized by central obesity, impaired glucose metabolism, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), and hypertension, in the pathogenesis and exacerbation of male reproductive issues [21,22], particularly in sexual dysfunction [23]

10.3389/fmicb.2023.1189434 44

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Together, these findings support a role for ABHD11 in controlling CD8 + T cell differentiation, with implications for 2-OG metabolism and oxygen tensions in contributing to the phenotypic differences between T cell states (Fig