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In addition, antioxidant therapy (such as N-acetylcysteine and Metadoxine) and nutritional support are also important components of the comprehensive treatment strategy for ALD (Singal et al., 2018)

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Effect of NAC therapy on the disease activity in different organs Our findings showed that disease activity in each organ based on BILAG score after treatment indicated a significant decrease in the NAC group compared to the baseline level in general ( P =0.018), mucocutaneous ( P =0.003), neurological ( P = 0.015), musculoskeletal ( P = 0.048), cardiorespiratory ( P = 0.047), renal ( P =0.025), and vascular ( P = 0.048) complications, other than hematological score (Table 3)

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