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In TMAO-treated macrophages, significant upregulation is observed in both M1 signature cytokines (including IL-1, IL-6, TNF-, Chemokine (C-X-C motif) ligand (CXCL) 9, and CXCL10) and key genes such as NLRP3 (77)

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[3] [4] [5] It is usually diagnosed in infancy or early childhood and, if left untreated, it is the most common genetic cause of infant death

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