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(20) The desired effects of these feminizing medications include the following: The development of breast tissue and female pattern fat distribution A decrease in testicle size A decrease in facial and body hair Potential side effects of this medication include the following (21): Blood clot development Elevated levels of serum triglycerides Changes in mood, affect, and potential worsening of pre-existing mental health illnesses

Mechanistic studies in preclinical models demonstrate that the presence of functional 3-adrenergic receptors is required for AOD 9604 activity

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[23], the risk of developing vitamin B12 deficiency was significantly correlated with the duration of metformin intake, with a ninefold increased risk beyond 10 years and a 4.6-fold increased risk for a treatment duration between 4 years and 10 years