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doi: 10.1016/j.yexcr.2017.01.002 19 YazdaniHOKaltenmeierCMorderKMoonJTraczekMLoughranPet al

Disease states that affect intra-portal insulin levels by increasing insulin resistance causing compensatory intra-portal hyperinsulinemia or by decreasing pancreatic -cell insulin secretion causing intra-portal hypoinsulinemia results in changes to hepatic IGF-I synthesis and secretion, and consequently changes in GH levels via the negative feedback loop

After 72 h, cells were washed and treated with Fento-1 (5 M, 72 h) or 0.2% DMSO without drug

10.1186/s13287-022-02900-5 444 ZhuS.WangA.XuW.HuL.SunJ.WangX

Both in vitro and in vivo experiments suggest that Phgdh mRNA is mainly expressed in astrocytes and minimally expressed in neurons (Furuya et al., 2000)

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