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These effects are thought to be mediated by alterations in gut microbiome due to acid suppression which can lead to bacterial translocation, subsequent infection, and higher rates of hospital readmission

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For example, a key myeloid checkpoint involved in the abscopal effect, CD47, has been shown to be overexpressed in radioresistant tumors from multiple types of primary tumor, including breast cancer [119] and a model of glioblastoma [120]

Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma

35 As discussed earlier, trauma, coupled with an associated genotype, can damage keratinocytes, leading to the expression of IFN and TNF, activation of dendritic cells, and production of IL-23