glutathione biosynthesis pathway in yeast Schematic representation of the sulfur amino-acid yeast. The Glutathione-Related Enzymes and Proteins: A

Oxidative stress can lead to the oxidation of low - density lipoprotein (LDL) cholesterol, a major factor in the development of atherosclerosis

Furthermore, since GSH redox imbalance seems to be specifically observed in some brain regions of autistic patients (37, 43), we measured GSH content in prefrontal cortex (PFC), dorsal striatum (DS), nucleus accumbens (NAc), amygdala (AMY), cerebellum (CER) and hippocampus (HIPP) of VPA-exposed animals, in order to understand if brain region-specific GSH variations may contribute to VPA-induced autistic-like traits

ALA supplementation can support glutathione production

Lieber C S, Relationships between nutrition, alcohol use, and liver disease,Alcohol Res Health

6j), confirming the dependency of GSH-deficient FoB on glycolysis

During iron overload conditions, excess iron is involved in the generation of free radicals, lipid peroxidation, and DNA damage, which in turn promotes ferroptosis