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Despite these limitations, the study has several strengths

Furthermore, in the tumor microenvironment, lactate can polarize macrophages toward a pro-angiogenic phenotype characterized by vascular endothelial growth factor (VEGF) production, which facilitates tumor progression [107]

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Attia FM, Maaty A, Kalil FA: Circulating endothelial cells as a marker of vascular dysfunction in patients with systemic lupus erythematosus by real-time polymerase chain reaction