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These factors interact and cause cerebral blood vessel alteration and vulnerability, once the intravascular pressure breaks through the threshold or blocks, the blood supply suddenly interrupts

As such, due to the multifaceted nature of chronic wound pathogenesis and susceptibility to abnormalities in ROS balance, interest in the role of ROS in wound healing, as well as the potential applicability of targeting ROS therapeutically, has grown significantly in recent years 14

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Among these signaling cascades, mTOR has a major role in tumorigenesis when abnormally expressed in cancer cells, as it influences multiple signaling networks, impacting apoptosis, growth, and autophagy [37]