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Interestingly, plant growth improved with increasing Pb levels and nitrogen (N) addition, with shoot biomass increasing from 1.04 g (control) to 3.81 g under Pb and N co-application

394 Aside from the direct effects of brain BAs, peripheral BAs provide signals to the CNS indirectly via the TGR5-dependent GLP-1 pathway and FXR-dependent FGF15/19 pathway