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Given these findings, the present study concludes that Vans effects are largely evident in stress-induced or disease conditions and not in normal models, which aligns with the present observations of no behavioral or biochemical changes in healthy control animals

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doi: 10.1016/j.jocrd.2012.10.003

Nagler A, Ohana M, Shibolet O, Shapira MY, Alper R, Vlodavsky I, Pines M, Ilan Y

Notwithstanding that, the picture during critical illness is uncertain as dynamic changes in plasma cortisol and aldosterone during this time are well-recognized though poorly understood, and furthermore tissue resistance to steroid hormones in sepsis is strongly suspected to exist (320)