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Am J Hum Genet 33 (1): 3643

In models of hind limb ischemia, it accelerated blood flow recovery and increased vessel density, highlighting its pro-angiogenic properties

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The pulsatile nature of this release is clinically significant: it mimics endogenous GH secretion rhythms, preserving downstream IGF-1 production, protein synthesis, and fat oxidation without the sustained GH elevation that can impair insulin sensitivity

Fatigue is a documented side effect of tirzepatide, particularly during the first 4 to 6 weeks of titration

however, vascular complications were not improved, most likely due to the excessive SOD-catalyzed formation of hydrogen peroxide, which causes endothelial damage (Rochette et al