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Evidence for a role of oxidative stress in populations with schizophrenia includes polymorphisms in key GSH pathway genes and altered levels of antioxidants (with correlations between levels and severity of symptoms).75 Oxidative stress may lead to changes in lipid membranes, mitochondrial dysfunction and alterations to DNA and proteins

Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction

2001;52(1-2):35-41.[DOI] 62

Older AIDS patients produce less GSH, which weakens their already fragile immune systems and decreases insulin sensitivity

Cancer 18 , 744757 (2018)

For example, coupling metrics such as temporal changes in the Treg/Th17 ratio, activity of the uNKDSC axis, signaling strength in the VEGFeNOS pathway, and indicators of mitochondrial metabolic performance could potentially be used to construct a mechanism-based RPL interaction map