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Several recent studies employing this methodology have uncovered that traditional memory-enhancing formulas regulate PI3K/AKT, Nrf2, MAPK, and NF-B pathways key nodes in the AD signaling network ( 2.5.1 Multi-omics approaches and systems biology in Alzheimers research Recent advances in multi-omics technologiesincluding transcriptomics, metabolomics, proteomics, and spatial transcriptomicshave opened new avenues for elucidating the molecular mechanisms through which natural products influence AD pathogenesis (Ma et al., 2024a)