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A review published in Gynecological Endocrinology by Calleja-Agius and Brincat (2012) described a strong correlation between skin collagen loss and oestrogen deficiency, noting that oestrogen replacement after menopause increased collagen content, dermal thickness and elasticity (PMID: 21970508)

Future studies utilizing conditional knockout models and endogenous tagging approaches will be valuable in further validating these findings

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Collectively, these findings suggest that exercise training exerts anti-oxidative effects through regulating the activity of enzymes, nuclear factors, and oxygen-free radicals

Tramutola A, Di Domenico F, Barone E, Perluigi M, Butterfield DA

and the degradation reaction of polyamines (PAs) from the chemical reactions of diamine oxidase (DAO) and polyamine oxidase (PAO)