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a higher bacterial burden was observed in zebrafish embryo following AhR inhibition with CH-223191 than in the untreated control group (104)

doi: 10.1016/j.immuno.2021.100004 126 LinMHuangZChenYXiaoHWangT

Second, nobody knows the long-term safety profile

Furthermore, a UK Biobank study of over 350,000 adults found that poor sleep quality, extreme sleep durations, and permanent NSW were linked to higher blood pressure and elevated pro-inflammatory markers, including CRP and leukocyte counts