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Description

Nature 368 , 502 (1994)

These compounds prevent IB degradation and p65 nuclear translocation, thereby reducing the expression of pro-inflammatory cytokines (TNF-, IL-6, IL-1) and adhesion molecules

These processes involve interactions in which one of the binding partners VpreB is initially unfolded

MMPs mediate the degradation of collagen and other extracellular matrix components within the fibrous cap, thereby disturbing the dynamic balance of collagen synthesis and degradation that underlies plaque stability.When collagen degradation becomes relatively enhanced and compensatory synthesisprimarily mediated by vascular smooth muscle cellsis insufficient, the structural integrity of the fibrous cap may be compromised