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Bioeng Biotechnol

Exosomes released by numerous types of cells and contain a vast spectrum of bioactive components including proteins, lipids, and nucleic acids

This decrease is probably caused by glutathione-degrading enzymes in S

Knockout of prolyl hydroxylase domain-containing protein 2 (PHD2) stabilized HIF-1 protein and activated HIF-1 signaling, which transcriptionally upregulated glutaminase 1 ( GLS1 ) expression leading to a decrease in ROS production and increases in cellular GSH levels, GSH/GSSG, and cell survival in murine periosteal progenitor cells, suggesting that HIF-1 signaling promotes glutaminolysis to provide glutamate for GSH synthesis (96)

Costa-Prez, A., Nez-Gmez, V., Baenas, N., et al

Our findings reveal an unexpected role for GPX2 in modulating pancreatic and hepatic cell fate decisions and provide insights into the intricate interplay between oxidative stress and cell fate determination during hPSC differentiation into endoderm derivatives, with emphasis on pancreatic endocrine cell development