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Blocking interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNF-) signaling, which decreases TRPA1 protein expression, has been demonstrated to alleviate neuropathic pain in rats with BIPN (Li et al., 2018

Considering the notion has been raised that sub-clinical presentation of konzo exists, these measures may allow for the identification of individuals who show similar reduced antioxidant capacity as those with konzo, but who do not show a visible physical disability, enabling the overdue refinement of the clinical features associated with this disease 3,42

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Globally, ~5.25 million individuals are living with CRC, with new cases expected to rise to 3.2 million by 2040 (3)

15 min before a dose of vehicle (water by oral gavage)