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Studies on endometriosis have shown that metformin exerts potent anti-NF-B effects, alleviating disease progression, and it has demonstrated the potential to target pro-inflammatory molecules in endometriotic cells (Takemura et al., 2007), macrophages, and vascular smooth muscle cells in vitro (Isoda et al., 2006), in obese mice (Hyun et al., 2013), and in rat models of endometriosis (Jamali et al., 2021

J Endocrinol 204:165172 Zhu HJ, Wang X, Pan H, Gong F, Zhang D, Li N, Wang L, Yang H (2014) Serum levels of the adipokine zinc-2-glycoprotein are decreased in patients with hypertension

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-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer

Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, et al

Felis E, kalka J, Sochacki A, Kowalska K, Bajkacz S, Harnisz M, Korzeniewska E (2020) Antimicrobial pharmaceuticals in the aquatic environmentoccurrence and environmental implications