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It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications

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Unsaturated fatty acids, including oleic acid (C18:1), linoleic acid (C18:2) and -linolenic acid (C18:3), have been demonstrated to accelerate the protein degradation of TYR by activating one of these two pathways, leading to anti-melanogenesis activity (120)

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Biological, physiological, and pharmacological aspects of ghrelin