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This further progressed to systemic inflammation, characterized by the leakage of TLR4 ligands into the blood, affecting the brain homeostasis via the bloodcerebrospinal fluid barrier (77)

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Furthermore, MMCC combined with -PD-L1 therapy significantly suppresses tumor growth, attributed to enhancing antigen-specific CD8 + T cell responses and DC maturation, and downregulating the proportion of Tregs (Figure 9E)