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The brainstem, which has been implicated to be affected in PASC, explaining the broad spectrum of symptoms, particularly pain and autonomic symptoms [156], has been found to show glucose hypometabolism in patients (among other regions) [47, 53, 89]

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However, the efficacy of folate and B12 interventionsmay vary across individuals due to genetic polymorphisms, such as MTHFR variantshighlighting the importance of incorporating genomic profiling into personalized supplementation strategies