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Therefore, STING played a regulatory role during the development of arthritis by modulating B cell functions, and it would be interesting to explore whether the function of B cell subtypes (such as regulatory B cells) could be regulated by cGAS-STING signaling in RA

Though useful for accounting for study endpoint events in a rapidly fatal disease (i.e., death versus study completion versus trial withdrawal), combined outcomes suffer from issues with cross-trial validity and weighting the importance of relative contributions to outcome (death versus disease progression versus loss of follow-up) in creating the summed rank model [51]

Prophylactic medications such as tizanidine (prescription needed) can also help

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